ABSTRACT
Objective@#To identify factors affecting adherence to medication, a subjective questionnaire survey was administered to schizophrenia patients regarding the prescribed antipsychotic formulations. @*Methods@#We evaluated the patients’ satisfaction and dissatisfaction with prescribed antipsychotic formulations, and patients answered the Drug Attitude Inventory-10 Questionnaire (DAI-10). Inclusion criteria for patients are as follows:age between 20 and 75 years and taking antipsychotic agents containing the same ingredients and formulations, for at least 1 month. @*Results@#In total, 301 patients answered the questionnaire survey. Tablets were found to be the most commonly used antipsychotic formulations among schizophrenia patients (n = 174, 57.8%), followed by long-acting injections (LAIs, n = 93, 30.9%). No significant differences in the formulation satisfaction level and DAI-10 scores were observed between all formulations. Formulations, except for LAI, were selected by physicians in more than half of the patients.Patients who answered “Decided by consultation with physicians” had significantly higher satisfaction levels and DAI-10 scores compared to those who answered “Decided by physicians” (4.11 ± 0.77 vs. 3.80 ± 1.00, p = 0.0073 and 6.20 ± 3.51 vs. 4.39 ± 4.56, p ＜ 0.001, respectively). Satisfaction levels moderately correlated with DAI-10 scores (r = 0.48, p ＜ 0.001). @*Conclusion@#No formulation had a high satisfaction level in all patients, and it is important to be reflect the patients’ individual preferences in pharmacotherapy. Shared decision-making in the selection of the formulations is seen to be useful for improving medication adherence.
ABSTRACT
<b>Introduction</b>: Amyloidosis is a variety of symptoms, such as organ failure and peripheral neuropathy amyroid protein is deposited in the systemic organs. We report a case of ketamine was effective for vulba referred pain in end stage. <b>Case report</b>: A 72-year-old male patient in end-stage primary generalized amyloid light-chain amyloidosis experienced excruciating pain in his genitalia about four times daily, lasting from tens of seconds to three minutes. No abnormal findings were noted in the genitalia. Bowel movement and large amounts of peritoneal dialysis fluid triggered excessive traction of the glans penis, which caused the excruciating pain. Referred pain originating from the pelvic plexus was suspected. Continuous infusion of ketamine was started at 50 mg/day for pain relief, which eliminated his pain, and the patient passed away 17 days later. <b>Conclusion</b>: The reason a small dosage of ketamine was effective, we consider there is a possibility of recovery from central sensitization effect of NMDA receptor antagonist worked effectively.